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Part One of this series provided information on the high costs associated with the two new treatment options, Sofosbuvir and OLYSIO™ (Simeprevir), as well as the efficacy of these treatments versus that of previous treatment options. While both of these drugs are highly effective, the high cost of treatment has many in the healthcare community worried that those most in need of treatment will be largely unable to access the drugs due to the prohibitive pricing model.
Bilirubin Elevations Total bilirubin elevation of more than 2.5xULN was observed in none of the subjects in the SOVALDI + peginterferon alfa + ribavirin 12 weeks group and in 1%, 3% and 3% of subjects in the peginterferon alfa + ribavirin 24 weeks, SOVALDI + ribavirin 12 weeks and SOVALDI + ribavirin 24 weeks groups, respectively. Bilirubin levels peaked during the first 1 to 2 weeks of treatment and subsequently decreased and returned to baseline levels by post-treatment Week 4. These bilirubin elevations were not associated with transaminase elevations.
Weeks Sofosbuvir + Peginterferon/Ribavirin Demonstrates Virologic Response Rates in G3 Hep C Patients
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Sofosbuvir CAS No.1190307-88-0;1064684-44-1
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Mylan launches generic Harvoni(R) (Ledipasvir/Sofosbuvir) under the brand name MyHep LVIR(TM) in India